Profile
Gabrielle Harker
My CV
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Education:
I went to Bishop’s Hatfield Girls School from Year 7 all the way to the end of Sixth form.
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Qualifications:
GCSEs – Mathematics, English literature, English language, biology, chemistry, geography, French, R.E., Graphic design, Art
A-Levels – Biology, Geography, Chemistry, Extended Project Qualification
Degree – Bachelor’s degree in Biomedical Sciences from the University of Bath
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Work History:
I started my first job at the age of 15 in my local hairdresser as an assistant every Saturday! It was super hard work, but constantly interacting with customers helped to improve both my confidence and communication skills. It also helped me to develop a good work ethic and punctuality, which I still benefit from in my role today.
During this time, I also carried out work experience at the University of Hertfordshire for a total of 5 days. I worked alongside master’s students to investigate muscle contraction. In an independent experiment, I evaluated the effect of a chemical, acetylcholine, and an inhibitor, atropine, on a rat intestine. First, I independently performed a dissection of the rat intestine and followed this with an investigation into the effects of varying concentration of acetylcholine and atropine on muscle contraction. This gave me my first real insight into the life of a laboratory scientist and fueled my love of science!
After 2 years, I left my job as a hairdresser’s assistant to work at Tesco as a store colleague in the general merchandise department. I had this job throughout most of my undergraduate degree, so balancing my work alongside my studies helped me to improve my time management and adaptability.
Additionally, during the summer of 2019 I took on the role of a camp counsellor at a summer camp in Maine. I had a fantastic time working with a team of 10 counsellors to supervise and care for a group of 30 children for 7 weeks. The role required a high degree of communication and teamwork to provide a seamless and enjoyable experience for the campers, as every activity required different skills, including both organisation and improvisation.
As part of my undergraduate degree, I worked as a placement student at the UK Health Security Agency. As part of a dedicated COVID-19 team, my role involved preparing and testing of human/animal blood to measure antibody levels to SARS-CoV-2 antigens. I was also part of the lateral flow device (LFD) team, my role was to investigate the newly developed lateral flow tests, using human saliva and nasal samples, to assess how successful they were at diagnosing COVID-19.
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Employer:
Wellcome Sanger Institute
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About Me:
Hi everyone! My name is Gaby, and I am a scientific research assistant for the Wellcome Sanger Institute currently living in Cambridge👩‍🔬. I really enjoy reading (particularly greek mythology), drawing, baking (especially gingerbread at Christmas) and movie nights 🙂
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Outside of work I am very into travelling having visited South-East Asia (Thailand, Vietnam, Cambodia and Bali) for 6 weeks over the previous summer! I have also travelled to much of Europe, as well as the Caribbean, America and Iceland. I love going on adventures, and some of the most scary/amazing things I have done include:
- Swimming with sharks (TWICE!!)
- Feeding a pack of wolves
- Waterskiing (as a camp counselor for Camp America)
Additionally, I love animals and own FIVE cats (I am a bit of a crazy cat lady!)
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My pronouns are:
She/her
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My Work:
I am a scientific research assistant working at the Wellcome Sanger Institute to investigate which genes are essential in human cells. To do this, I use a technology called CRISPR-Cas9 to mutate every single base in the DNA of HAP1 cells across all 20,000 genes!
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The project I am currently involved in uses CRISPR-Cas9 technology to investigate gene essentiality in cancer cells. Essentially, CRISPR-Cas9 targets a region of DNA that we are interested in and introduces a break in the DNA’s structure. When the break is made, a separate DNA molecule acts as a template to repair it. This template can be made in the lab and is designed to contain a mutation that we would like to introduce into the original DNA when it is repaired. When this is done, we have essentially changed the DNA and we can monitor how this affects cancer cell survival. This research will help us to understand cancer better, but also aid in the development of new cancer treatments.
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My Typical Day:
I start my day at 7am with a peanut butter bagel and coffee, before heading to work for 9am. As I am new to my job, I spend my day training in the lab learning lots of different experiments or reading scientific papers to help understand my work better. In the evening I like to go running as I am training for the Cambridge half marathon in March, and I am hoping to raise lots of money for Cancer Research UK as part of this 🙂
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I am currently training in the lab to be able to work on cancer cells in culture. This essentially involves growing cancer cells for approximately 15 days and editing their DNA halfway through. Once the DNA has been edited, we check the cells regularly to see if the edit has caused cell death or whether the cells remain alive. If the cell has died, we know that the edit has been made in a part of the DNA (termed a gene) that is essential for the cell. We can then use this to understand which genes cancer cells need to survive.
In addition to my training, I am reading lots of papers on scientific research that is related to my project. This helps me to gain a better understanding of my work, as well as the work being carried out by other amazing scientists!
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What I'd do with the prize money:
I would love to volunteer with GoEco to help teach children abroad about STEM and healthcare!
This is just one of the projects I would love to get involved in:
Volunteer in Zambia – Healthcare and Community Development | GoEco
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My Interview
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How would you describe yourself in 3 words?
Adventure-loving cancer researcher
What did you want to be after you left school?
I always wanted to be a Scientist
Were you ever in trouble at school?
Nope!
If you weren't doing this job, what would you choose instead?
Neurosurgeon, I am fascinated by the brain!
Who is your favourite singer or band?
Harry Styles
What's your favourite food?
Pasta always
If you had 3 wishes for yourself what would they be? - be honest!
1) To travel the world. 2) To cure all disease. 3) To pet a bear
Tell us a joke.
What do you call security guards working outside Samsung shops? Guardians of the Galaxy.
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